pyridine based chalcones: synthesis and evaluation of antioxidant activity of 1-phenyl-3-(pyridin-2-yl)prop-2-en-1-one derivatives
نویسندگان
چکیده
conclusions according to the obtained data, synthesized pyridine based chalcones (3a-3j) could be proposed as potential antioxidant lead compounds. background natural chalcones and also their synthetic derivatives have attracted increasing attention due to various pharmacological applications. development and discovery of new chalcones with antioxidant activities is one of the attracting areas in medicinal and natural product chemistry. results fortunately, compounds 3e (16.53 ± 1.21 µg/ml), 3g (58.85 ± 1.10 µg/ml) and 3i (58.73 ± 12.94 µg/ml) showed higher antioxidant activity (ec50 ± sd) in comparison with quercetin (87.24 ± 3.93 µg/ml) as reference agent in ferrous ion chelating method. furthermore, compounds 3g (4.82 ± 0.11 µg/ml) and 3h (6.33 ± 0.30 µg/ml) also exhibited an acceptable antioxidant property compared to trolox (3.83 ± 0.22 µg/ml) in teac method. none of synthesized compounds demonstrated significant antioxidant activity in dpph free radical scavenging as well as beta carotene bleaching tests. materials and methods all compounds were synthesized via an aldol condensation procedure in methanol or ethanol solvent at room temperature and characterization was carried out by 1hnmr, ir and ms spectroscopic methods. related melting points were also measured for each compound. objectives in the present study, a new series of pyridine based chalcones was synthesized and their antioxidant capacity was evaluated by beta carotene bleaching (bcb), dpph free radical scavenging, ferrous ion chelating (fic) activity and trolox equivalent antioxidant capacity (teac) methods.
منابع مشابه
Pyridine Based Chalcones: Synthesis and Evaluation of Antioxidant Activity of 1-Phenyl-3-(pyridin-2-yl)prop-2-en-1-one Derivatives
BACKGROUND Natural chalcones and also their synthetic derivatives have attracted increasing attention due to various pharmacological applications. Development and discovery of new chalcones with antioxidant activities is one of the attracting areas in medicinal and natural product chemistry. OBJECTIVES In the present study, a new series of pyridine based chalcones was synthesized and their an...
متن کاملSynthesis and Antimicrobial Activity of Some 2-[(4-Substituted-Phenyl-3-Chloro-Azetidin-2-One)-5-(2'-Methylamino-4-Phenyl-1', 3'-Thiazolyl-]-1, 3,4-Thiadiazoles
A new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n) using 2-amino-4phenyl-1, 3-thiazole as a starting material. The synthesised compounds have been screened in vitro for their antimicrobial acti...
متن کاملsynthesis and antimicrobial activity of some 2-[(4-substituted-phenyl-3-chloro-azetidin-2-one)-5-(2'-methylamino-4-phenyl-1', 3'-thiazolyl-]-1, 3,4-thiadiazoles
a new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n) using 2-amino-4phenyl-1, 3-thiazole as a starting material. the synthesised compounds have been screened in vitro for their antimicrobial acti...
متن کاملsynthesis and evaluation of anticancer activity of 1-(3-chloro phenyl)-2-piperazinone derivatives as potential farnesyltransferase enzyme inhibitors
متن کامل
1-Phenyl-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one
In the title compound, C(18)H(18)O(4), the dihedral angle between the mean planes of the aromatic rings is 7.39 (6)°. The dihedral angles between the linking C-C=C-C plane and the phenyl and benzene rings are 11.27 (5) and 4.20 (5)°, respectively.
متن کاملIsoquinoline Promoted Synthesis of alkyl 2-(1-alkyl-5-oxo-3-phenyl-2-thioxotetrahydro-4H-imidazol-4-yliden) acetate derivatives
Derivatives of thiazolidinone ring systems are known to act as anti-HIV infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. Due biological activities of thiazolidinones ring, several methods for their synthesis have been illustrated in literature. Imidazolidine-2-thiones were synthesized by the oxidative cyclization of 1-be...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
jundishapur journal of natural pharmaceutical productsجلد ۸، شماره ۳، صفحات ۱۲۵-۱۳۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023